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U.S. Route 222

U.S. Route 222, considered a spur of U.S. Route 22, runs from U.S. Route 1 in Conowingo, Maryland into Pennsylvania, where it passes through Lancaster, Reading and Kutztown before reaching its north end at Interstate 78 just outside of Allentown. It has a business route serving downtown Reading. The route's southern terminus used to be further south, in Perryville, Maryland.

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