Interstate 75 is Florida's western north-south Interstate highway corridor, running west from the Miami area along Alligator Alley to Naples, then turning north and paralleling the Gulf of Mexico to the state's far north, finally exiting into Georgia after 471 miles. Its original southern terminus was in downtown Tampa, utilizing what is now roughly the northern half of Interstate 275. By the 1970s, I-75 was re-routed to bypass the Tampa Bay area proper. Aside from I-275, it has two nominal spurs, I-175 and I-375, in St. Petersburg off I-275. State Road 826 connects I-75 with Interstate 95 in Broward County; Interstate 4 does the same in central Florida via Lakeland-Winter Haven and Orlando.

Interstate 75 south - Sarasota to Port Charlotte