U.S. Route 22 runs 338 miles in Pennsylvania from the West Virginia line in Washington County to the New Jersey line in Northampton County. It passes through Pittsburgh and the Lehigh Valley and also comes close to state capital Harrisburg. US 22 overlaps with U.S. Route 322 from Lewistown to just north of Harrisburg and Interstate 78 from Fredericksburg in Lebanon County to just northwest of Allentown.