U.S. Route 101 south - Mission District to Millbrae

In the Mission District of north San Francisco, southbound U.S. Route 101 makes its way away from its junction with cross-country Interstate 80, whose western terminus is just behind this spot. In the foreground, a ramp from US 101 south (which begins prior to its shifting course onto this particular freeway alignment) to I-80 west flies overhead. (5-8-2026)

The highway then passes under a ramp carrying northbound US 101 traffic from this freeway onto the Division Street freeway (which takes it through the Civic Center area of downtown) with a vertical height clearance of 15 feet. The straight movement exiting US 101 north onto I-80 east is exit 433C along US 101. (5-8-2026)

A tiny cutout US 101 shield follows exit 433. (5-8-2026)

Following that is a footbridge connecting two sections of San Bruno Avenue. (5-8-2026)

The freeway's next three exits, starting with Cesar Chavez Street, fall within a span of 1¾ miles. (5-8-2026)

The offramp to Cesar Chavez (exit 432) directly follows the 25th Street footbridge. (5-8-2026)

Afterward, drivetimes to the San Francisco airport, California State Route 92, and Daly City are posted on a variable message sign to the right. (5-8-2026)

The far-right southbound lane is set aside for traffic exiting onto Interstate 280 south toward Daly City. (5-8-2026)

I-280 is exit 431, while the next exit, Silver Avenue, half a mile away, is exit 430B. (5-8-2026)

The ramp from I-280 north to US 101 north flies overhead here. (5-8-2026)

Coming ¾ mile after exit 430B is exit 430A at Paul Avenue. (5-8-2026)

Southbound US 101 receives traffic from Silver Avenue at left. (5-8-2026)

The second exit from the next intersects Third Street and leads to the Cow Palace. Among other things, the Cow Palace was the original home of the NHL's San Jose Sharks when they were launched in 1991. (5-8-2026)

The Paul Avenue exit is up ahead. (5-8-2026)

Truck traffic bound for the nearby city of Brisbane is to use the Cow Palace exit. (5-8-2026)

The Cow Palace exit is 429B. (5-8-2026)

Exit 429A, half a mile away, intersects Tunnel Avenue and leads to the former site of Candlestick Park, once home to the NFL's San Francisco 49ers and MLB's San Francisco Giants. (5-8-2026)

This overhead sign points the way to Tunnel Avenue. (5-8-2026)

US 101's next 3 exits come within a span of as many miles. (5-8-2026)

US 101 reassurance sits before the next exit. It is also around here where US 101 leaves San Francisco for San Mateo County. (5-8-2026)

Exit 426 (Sierra Point Parkway) is half a mile away. (5-8-2026)

The area Brisbane Marina is served by the next 2 exits. (5-8-2026)

Exit 426 is straight ahead on the right. (5-8-2026)

The onramp from Sierra Point includes a ramp meter. (5-8-2026)

Drivetimes to the airport and California State Routes 92 and 84 are displayed by the VMS to the right. (5-8-2026)

The next 3 exits, beginning with the South San Francisco exit, are along the freeway's next 2 miles. (5-8-2026)

The South San Francisco exit is 425C. (5-8-2026)

The exit 425C gore sign. (5-8-2026)

Exit 425B leads to Oyster Point Boulevard East. (5-8-2026)

Exit 425A (Grand Avenue) is ¾ mile away, while exit 423A to the airport is 2¼ miles away. (5-8-2026)

Exit 425A (Grand Avenue) is ¾ mile away, while exit 423A to the airport is 2¼ miles away. (5-8-2026)

The next 3 exits up to Interstate 380 are 1¾ miles away. (5-8-2026)

Exit 424 (South Airport Boulevard) comes half a mile after Grand Avenue. (5-8-2026)

Exit 424 can be used to reach Produce Avenue, airport parking and a conference center. (5-8-2026)

A FasTrak express lane begins on the left a mile away. (5-8-2026)

Meanwhile, exit 423A leads to SFO's rental car and parking facilities. (5-8-2026)

Exit 424 is half a mile prior to exit 423B (I-380) and 423A. (5-8-2026)
